Nuclear Lamins
نویسندگان
چکیده
منابع مشابه
Nuclear lamins in cancer.
Dysmorphic nuclei are commonly seen in cancers and provide strong motivation for studying the main structural proteins of nuclei, the lamins, in cancer. Past studies have also demonstrated the significance of microenvironment mechanics to cancer progression, which is extremely interesting because the lamina was recently shown to be mechanosensitive. Here, we review current knowledge relating ca...
متن کاملNuclear Lamins a and B1
At the end of mitosis, the nuclear lamins assemble to form the nuclear lamina during nuclear envelope formation in daughter cells. We have fused A- and B-type nuclear lamins to the green fluorescent protein to study this process in living cells. The results reveal that the A- and B-type lamins exhibit different pathways of assembly. In the early stages of mitosis, both lamins are distributed th...
متن کاملNuclear lamins of erythrocyte and liver.
Lamins A, B, and C are the most abundant proteins in a residual nuclear envelope fraction derived from the nuclear lamina. They have been separated and identified in several tissues by two-dimensional electrophoresis based on their isoelectric points and molecular weights. Molecular weights and ionic properties have been conserved in the evolution of chickens and rats. Lamins purified from chic...
متن کاملA role for nuclear lamins in nuclear envelope assembly
The molecular interactions responsible for nuclear envelope assembly after mitosis are not well understood. In this study, we demonstrate that a peptide consisting of the COOH-terminal domain of Xenopus lamin B3 (LB3T) prevents nuclear envelope assembly in Xenopus interphase extracts. Specifically, LB3T inhibits chromatin decondensation and blocks the formation of both the nuclear lamina-pore c...
متن کاملNuclear Actin and Lamins in Viral Infections
Lamins are the best characterized cytoskeletal components of the cell nucleus that help to maintain the nuclear shape and participate in diverse nuclear processes including replication or transcription. Nuclear actin is now widely accepted to be another cytoskeletal protein present in the nucleus that fulfills important functions in the gene expression. Some viruses replicating in the nucleus e...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2010
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a000547